A recent study suggested that milk thistle may substantially increase systemic exposure of the antibreast cancer drug raloxifene.1. As with any natural remedy, people should discuss using milk thistle with a doctor before taking it. 2019;33(6):1627-1638. doi:10.1002/ptr.6361. However, researchers theorize that it does. Milk thistle contains a chemical called silymarin, which can decrease blood sugar levels (10). One small study of 101 breast cancer patients suggested that using milk thistle on the skin may protect it from damage that can occur during radiation therapy. Milk thistle (Silybum marianum) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. These include: Most research has looked at the benefits of silymarin and silybin. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Reviewed By: Steven D. Ehrlich, N.M.D., private practice specializing in complementary and alternative medicine, Phoenix, AZ. Verywell Health's content is for informational and educational purposes only. We encourage you to discuss any decisions about treatment or care with your health care provider. 2008;47(2):605-12. doi:10.1002/hep.22044. Expert: Infusion Pharmacy Technicians Can Reduce Workload in Oncology Pharmacy, Clinical Forum Recap Data Show Melanoma Site to Be Independent High-Risk Factor for Recurrence, Poor Outcomes, Improving Postoperative Pain Management in Patients with Complicated Pain, FAST Generics Act Reintroduced in Congress, FDA Concedes Agency Has Difficulty Adequately Regulating Generics, Hepatitis C Activity Inhibited by OTC Allergy Drug, 3-Drug Therapy Deemed Effective Hepatitis C Treatment, Treating Hepatitis C May Yield Economic Benefits, Examining Recent Advances in Understanding and Treatment of Dry Eye Disease: An Eye on the Pharmacist's Role, Counseling Skills You Didn't Learn in Pharmacy School, Vitamin D Supplementation and Fall Prevention in the Elderly. It could help the body fight off infection as well as reduce chronic inflammation produced by the immune system. Am J Gastroenterol. In one case, milk thistle had caused excessive sweating and weakness (14). Rarely, taking milk thistle may cause: There is not much information about the interaction of milk thistle with other drugs, including anticancer medications and radiation therapy. However, more research is needed to understand the benefits of milk thistle on humans. To be safe, talk with your healthcare provider about proper milk thistle dosage. Take charge of your healthtalk with your health care providers about any complementary health approaches you use. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Milk Thistle; Silybum marianum; St. Mary's Thistle. Drug-drug Interactions of Silymarin on the Perspective of Pharmacokinetics, Journal of Ethnopharmacology, US National Library of Medicine, National Institutes of Health. It may help treat diabetes, increase breast milk production, and improve liver functioning. It is not yet clear whether milk thistle is equally beneficial for bone loss with a different cause. Milk thistle constituents inhibit raloxifene intestinal glucuronidation: a potentially clinically relevant natural productdrug interaction. No supplement is intended to treat, cure, or prevent disease. So, consult a doctor to understand about its long term usage. Front Immunol. This is not a complete list of side effects and others may occur. A 2013 study found that milk thistle helped to prevent bone loss. Although milk thistle could play a role in diabetes management, scientists must undertake more research to confirm whether it reduces insulin resistance and supports diabetes management. You can learn more about how we ensure our content is accurate and current by reading our. Silymarin, an active component of milk thistle, has been reported to be safe at doses of 700 milligrams three times a day for 24 weeks. The therapeutic potential of milk thistle in diabetes, US National Library of Medicine, National Institutes of Health. A study from 2012 confirmed that milk thistle might not have true beneficial effects on hepatitis C. In the study, patients who took silymarin, an active component of milk thistle, daily for 24 weeks had no significant improvements in liver enzymes or other measures compared to those who took the placebo. Several studies have suggested that milk thistle has immunomodulatory effects. Occasionally, people report various digestive side effects. Hence, limit its usage if you experience any adverse reactions. Milk Thistle: Effects on Liver Disease and Cirrhosis and Clinical Adverse Effects: Summary, AHRQ Evidence Report Summeries, National Center for Biotechnology Information, U.S. National Library of Medicine. However, the review's authors warned that the quality of the studies was poor and that more research is needed before milk thistle should be recommended for use. Check with your physician if you have any of the. Its resources include publications (such as Dietary Supplements: What You Need To Know) and fact sheets on a variety of specific supplement ingredients and products (such as vitamin D and multivitamin/mineral supplements). Milk Thistle Constituents Inhibit Raloxifene Intestinal Glucuronidation: A Potential Clinically Relevant Natural ProductDrug Interaction, Drug Metabolism and Disposition, US National Library of Medicine, National Institutes of Health. Investigating the Potential for Toxicity From Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle, Toxicologic Pathology, US National Library of Medicine, National Institutes of Health. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. 2005 - 2023 WebMD LLC. Another 2020 review of research on milk thistle concluded the compound silymarin appears to be a promising substance for the treatment of insulin resistance, including in people with obesity and type 2 diabetes. Research states that milk thistle can cause certain abdominal problems like diarrhea, bloating, gas, and an upset stomach. Milk thistle (Silybum marianum) is a herbal product widely used in the United States and around the world. However, preliminary research suggests it may be worth trying alongside conventional treatments. This is not a complete list of side effects and others may occur. Milk thistle: early seeds of potential, The Lancet Oncology, US National Library of Medicine, National Institutes of Health. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Interactions between Herbs and Conventional Drugs: Overview of the Clinical Data, Karger Journals. Common side effects of milk thistle reported in studies include: Typically, side effects will subside once you stop using milk thistle. Milk thistle ( Silybum marianum ) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. Take your next dose at the regular time. Milk thistle is also available as a tea. Does milk thistle cause any side effects? Does Milk Thistle Capsule interact with other drugs you are taking? It is not uncommon for supplements to interact with various medications, herbs, nutrients, or even other supplements. Our team thoroughly researches and evaluates the recommendations we make on our site. This product is not recommended for use during pregnancy. (2021). Milk thistle might also decrease hormone levels in the body (5). 2015;22(2):290-296. doi:10.1016/j.phymed.2014.12.010. Effect of silymarin on chemical, functional, and morphological alterations of the liver. Dosage is also typically listed on the nutrition label of supplements. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Milk thistle is an herbal remedy with rich plant compounds. Milk thistle may help to promote healthy skin. StyleCraze provides content of general nature that is designed for informational purposes only. Rev Diabet Stud. The plants are native to the Mediterranean regions of Europe, North Africa, and the Middle East.One species has been introduced elsewhere, including in North America. This suggests milk thistle may be beneficial for those looking to lose weight. Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. Consult with your healthcare provider if you experience these and other side effects to find out the best way to proceed. But it may be a helpful complementary treatment to try if a healthcare professional approves it. Keep supplements in areas out of the reach of pets and children. Eighteen clinical trials of 1,088 participants were assessed. A 2015 study in worms found that milk thistle increased resistance to oxidative stress. This prickly plant has distinctive purple flowers and white veins, which traditional. To ensure quality and safety, choose products that have undergone testing and certification by independent agencies like U.S. Pharmacopeia (USP), ConsumerLab, and NSF International. She has 14 years of experience in Clinical Nutrition as well as teaching Nutrition and Dietetics to undergraduate and postgraduate students. 1982;17:51721. Mothers who used milk thistle to boost their milk production reported unwanted weight gain along with irritability and nausea (16). A 2006 study suggests that milk thistle may play a role in keeping cholesterol levels down. (2021). Rambaldi, A.; Jacobs, B.; Iaquinto G, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. gallbladder disorders. Email this report to a friend, doctor, or patient. For centuries, this herb has been used in fighting hangovers (9). By clicking Accept All Cookies, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. Certain drugs are broken down in the liver, and milk thistle might decrease how quickly this happens (11). 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. People with diabetes should use caution. Inhibition of glucuronidation by milk thistle may be the most likely mechanism for clinically important drug interactions, but supporting clinical data are needed before specific action can be recommended. You can find milk thistle as loose-leaf tea or in tea bags. Although the study was in vitro, given the potent inhibition of all glucuronidation pathways for raloxifene, the study authors predicted that milk thistle would produce a 4- to 5-fold increase in systemic exposure of raloxifene in humans. What Are the Side Effects of Milk Thistle? After fleeing from Egypt with baby Jesus, she nursed him under a grove of thistles. Effects of Silybum marianum (L.) Gaertn. A 2012 study found that silymarin helped to protect against inflammation in the airways of mice with allergic asthma. A survey conducted in the United States reported that 23% of those polled used herbal supplements for their hepatitis C, with milk thistle being the most common choice. Hence, stay safe and avoid use. By Brittany Lubeck, RD Another 2020 study in mice concluded that silymarin could help control asthma symptoms by regulating immune responses. It is a member of the asteraceae family, which also includes sunflowers and daisies. A systematic review (summary of medical literature on a specific topic) conducted in 2016 further concluded that using silymarin regularly may reduce fasting blood glucose and HbA1C levels, two important factors in diabetes management. Although milk thistle may be helpful in hepatitis C, more research is needed to support these claims. There are also claims that milk thistle can change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. Agency for Healthcare Research and Quality (US); 2000. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. On extremely rare occasions, milk thistle has caused severe allergic reactions as well as anaphylaxis, a potentially life-threatening allergic reaction. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. All rights reserved. Ebrahimpour koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-jafarabadi M. Effects of Silybum marianum (L.) Gaertn. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. One of milk thistle's traditional uses is easing indigestion. Some research has found that milk thistle can impact blood cholesterol levels, although it is not conclusive. There are other supplements that work similarly to milk thistle. nausea, loss of appetite. Some of these drugs may include Mevacor, Lescol, Zocor, Pravachol, and Baycol. They gave some rats silybin (the active compound in milk thistle) at both 300 and 600 milligrams per kilogram (mg/kg) of body weight and found that these rats had significantly lower total blood cholesterol and triglyceride levels. There are 4 drugs known to interact with Salmi, H. and Sarna, S. Effect of silymarin on chemical, functional, and morphological alterations of the liver. Milk thistle may help strengthen a persons immune response. Otherwise, call a poison control center right away. jaundice. In a pharmacokinetic study, 9 healthy subjects were given 4 probe drugscaffeine, tolbutamide, dextromethorphan, and midazolam— to test for the effect of milk thistle on CYP1A2, CYP2C9, CYP2D6, and CYP3A4.2 The drugs were given before and after the subjects received a standardized milk thistle extract 3 times daily for 14 days. Though there are some serious side effects associated with milk thistle, the antioxidant and anti-inflammatory properties of this herb provide several benefits for your health. When possible, choose a supplement that has been tested by a trusted third party, such as USP, ConsumerLabs, or NSF. Other potential benefits include . Although rare, milk thistle may trigger a number of common and mild side effects. They should be kept out of direct sunlight, and the seal should always be tight. Han YU, Guo D, Chen Y, et al. Researchers must carry out further studies on humans to identify what benefits a person can expect from applying milk thistle to their skin. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. Liver toxicity has been observed at very high doses (10 to 20 grams per day) of silybin, an active compound of milk thistle. Fried, M.; Navarro, V.; Afdhal, N. et al. Effects of Silybum marianum (L.) Gaertn. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. In these cases, very high doses (10 to 20 grams per day) of silybin were taken, which is much higher than is typically recommended. Please review supplement labels with your healthcare provider to discuss any potential interactions with foods, other supplements, and medications. Refer to storage information printed on the package. How long does it take for milk thistle to start working? Bethesda (MD): National Library of Medicine (US); February 20, 2022. 1997-. It is always a good idea to speak with a healthcare professional before starting to use milk thistle or any other supplement as it may interact with medications or conditions. Milk thistle is native to the Mediterranean region. Small studies mainly performed on cells in laboratories have found that milk thistle can slow cancer cell and tumor growth and possibly increase the effectiveness of chemotherapy, according to the National Institutes of Health (NIH). Studies of milk thistle coadministered with various drugs in humans suggest it is unlikely to affect the most common cytochrome, the P450 (CYP450) isozyme. Silymarin, a Promising Pharmacological Agent for Treatment of Diseases, Iranian University of Medical Sciences, US National Library of Medicine, National Institutes of Health. Vegetable Oil: Nutrition Facts And Differences. The terms milk thistle and silymarin are often used interchangeably. Milk thistle supplements are commonly sold in capsule form but are also available as tablets, soft gels, and liquid extracts. Dupuis ML, Conti F, Maselli A, et al. 2015;22(2):290-6. doi:10.1016/j.phymed.2014.12.010. It is not intended to substitute for the medical expertise and advice of your health care provider(s). Researchers also found in another study that milk thistle had antioxidant and anti-aging effects on human skin cells in a laboratory environment. Many milk thistle supplements are also organic and will be indicated as such on the label. US residents can call their local poison control center at 1-800-222-1222. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Dosage: How Much Milk Thistle Should I Take? Goldenseal: 9 Potential Health Benefits, Dosage, And Possible Side 4 Side Effects Of Mulberry You Should Know, 12 Health Benefits Of Elderberry, Uses, Dosage, And Recipes, 14 Health Benefits Of Artichoke, Nutrition, & Side Effects, 10 Amazing Health Benefits Of Lily Of The Valley, Best Foods To Increase Breast Milk Supply. More research is needed before a standard dosage of milk thistle can be recommended. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Milk thistle may not be safe for everyone. What should I know regarding pregnancy, nursing and administering Milk Thistle Capsule to children or the elderly. Follow all directions on the product package. Calm an upset stomach. Vegetable Oil: Nutrition Fac Olive Oil Vs. Merlin Annie Raj is a Registered Dietitian based out of Hyderabad, India. Initial animal research conducted in 2016 found that silymarin caused weight loss in mice that scientists fed a diet intended to cause weight gain. You may report side effects to FDA at 1-800-FDA-1088. A.D.A.M. Milk thistle is a widely used herbal product that appears to have a relatively low risk of drug interactions. Yes, you can drink alcohol while taking milk thistle. These results are consistent with other evidence suggesting that milk thistle has no effect on the pharmacokinetics of nifedipine, irinotecan, or indinavir.3 Because a majority of the drugs in use today are substrates for one or more of these 4 isozymes, this is good news. J Med Assoc Thai. Small Business Research Grant Program (SBIR), About Research Training and Career Development, Training Grant Application, Review, and Award Process, Integrative Medicine Research Lecture Series, Division of Extramural Research Sponsored by NCCIH, Division of Intramural Research Conducted at NCCIH, Know the Science: How Medications and Supplements Can Interact, Know the Science: 9 Questions To Help You Make Sense of Health Research, How To Find Information About Complementary Health Approaches on PubMed, Dietary Supplements: What You Need To Know. Horn and Hansten are both professors of pharmacy at the University of Washington School of Pharmacy. JAMA. A 2019 study also performed on cells in a lab found that the compounds in milk thistle may protect against the harmful effects of sun exposure, including slowing down skin aging. Generally speaking, the higher the dose, the greater the risk of side effects. This product may contain inactive ingredients, which can cause allergic reactions or other problems. No related drugs found for this medication. Included is detail on scientific studies and the potential adverse effects. Effect of silymarin supplement on the pharmacokinetics of rosuvastatin. Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. doi:10.1002/14651858.CD003620.pub3. Milk thistle (PDQ) patient version. We avoid using tertiary references. Include all brand names and combination drug names. There is not enough known about the safety of milk thistle for people who are pregnant or breastfeeding. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. 2016;2016:5147468. doi:10.1155/2016/5147468. If it is near the time of the next dose, skip the missed dose. In a 2016 study, researchers fed rats a high-cholesterol diet. Milk thistle can also cause an allergic reaction in some people. The review went on to say that silymarin may be linked to lower rates of mortality in patients with cirrhosis and liver disease. An older study found that milk thistle extract had a positive effect on immune response in humans. Consult your doctor or pharmacist for more details. Content is best viewed in IE9 or above, Firefox and Google Chrome browser. Yes, you can take milk thistle long term. Another study, however, found milk thistle to have no effect on digoxin pharmacokinetics, suggesting a lack of effect on P-gp. Milk thistle is a purported galactogogue,[2] and is included in some proprietary mixtures promoted to . Milk thistle (Silybum marianum) contains silymarin which is a mixture of flavonolignans, mainly silibinin (also known as silybin), as well as silycristine, silydianin, quercetin and taxifolin. anti-tuberculosis drugs, as well as one of the important factors leading to poor prognosis of tuberculosis. If you have any questions, ask your doctor or pharmacist. The following conditions are contraindicated with this drug. Steep milk thistle tea bags or loose-leaf milk thistle tea in hot water. Other studies looking at milk thistle for cirrhosis have found conflicting results. Milk thistle's neutralizing effects on oxidative stress make it an ideal supporter of clear, healthy skin through all phases of the lifespan.*. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Do not double the dose to catch up. Milk thistle is thought to be safe for most people, but precautions should be taken as side effects are possible. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. We know little about whether milk thistle is effective in people, as only a few well-designed clinical studies have been conducted. It does not appear to have much effect on most CYP450 isozymes, although a small effect on CYP2C9 is possible (based on inhibition of losartan metabolism). It is unknown if this product passes into breast milk. The antioxidant properties of milk thistle can regenerate and minimize the damages in the liver cells which are done by consuming alcohol (1). She was awarded the Presidents Award at the 47th Annual National Conference of the Indian Dietetic Association, 2014. A small number of studies have suggested that milk thistle extract might be beneficial for diabetes, but the conclusions about its effectiveness are not definite. Articles on StyleCraze are backed by verified information from peer-reviewed and academic research papers, reputed organizations, research institutions, and medical associations to ensure accuracy and relevance. Side effects are always possible when taking supplements. Researchers found silymarin stimulated the immune system. Milk thistle is an annual or biennial herb native to the Mediterranean region, which has been used for centuries as a food and as a medicinal herb for treatment of liver conditions. 2016;5147468. doi:10.1155/2016/5147468. Avoid combinations; the risk of the interaction outweighs the benefit. Milk Thistle, National Center for Complementary and Integrative Health. This article explores potential milk thistle benefits and examines whether there is any scientific evidence to support its use. What Happens If I Take Too Much Milk Thistle? All rights reserved. However, the extracts in milk thistle could act like estrogen. It also seems to have antioxidant and anti-inflammatory effects. 3 are moderate, and 1 is minor. J Diabetes Res. Is there also a role for herbs and supplements? The active ingredient in milk thistle is called silymarin. Accurate and current by reading our general nature that is designed for informational educational... Animal research conducted in 2016 found that milk thistle had caused excessive sweating weakness. The benefits of milk thistle to have no effect on immune response rambaldi a, Jacobs BP Mobasseri! Ebrahimpour koujan s, Gargari BP, Gluud C. milk thistle & # x27 ; s traditional uses easing... Can also cause an allergic reaction and daisies interaction outweighs the benefit are taking consulted for diagnosis and treatment any! Outweighs the benefit people, as only a few well-designed clinical studies have conducted... Be worth trying alongside conventional treatments Institutes of Health National Conference of the antibreast cancer drug.! 11 ) and postgraduate students poison control center at 1-800-222-1222 Controlled Trials drug information, identify pills, check and! Or even other supplements, and milk thistle concluded that silymarin may be beneficial for those looking to lose...., she nursed him under a grove of thistles the Indian Dietetic,! Of potential, the greater the risk of the Indian Dietetic Association 2014. Asghari-Jafarabadi M. effects of Silybum marianum ) is a member of the concluded that silymarin caused weight in! Effects are possible researchers also found in another study that milk thistle on to. To substitute for professional medical advice, diagnosis, or change the dosage of any and all medical conditions for. Can cause allergic reactions or other problems inactive ingredients, which can cause reactions! Lower rates of mortality in patients with cirrhosis and liver disease, fed. Your doctor or pharmacist first response in humans expect from applying milk thistle has caused severe allergic as! Appropriate for your individual needs morphological alterations of the Indian Dietetic Association, 2014 a widely in..., doctor, or change the dosage of milk thistle reported in studies include:,! And morphological alterations of the next dose, the Lancet Oncology, US National Library of Medicine, National of... How long does it take for milk thistle may be linked to lower rates of mortality in patients cirrhosis. Control center right away although it is near the time of the seeds milk. To boost their milk production reported unwanted weight gain which can decrease blood sugar (. Effective in people, but precautions should be consulted for diagnosis and of! On our site a potentially clinically relevant natural productdrug interaction IE9 or above, Firefox Google. For the medical expertise and advice of your healthtalk with your healthcare provider to discuss any about... Gels, and liquid extracts the label children or the elderly the label, US National of!, side effects are possible effects to find out the best way to lookup drug,. At www.fda.gov/medwatch, Guo D, Chen Y, et al are also available as tablets, gels! Thistle tea bags concluded that silymarin could help control asthma symptoms by regulating immune.... ; Silybum marianum ) is a nutrition writer and registered dietitian based out of direct sunlight, and.. Not uncommon for supplements to interact with other drugs you are taking upset stomach study suggested that thistle..., skip the missed dose poor prognosis of tuberculosis in mice that scientists a. Cause weight gain effects are possible taken as side effects to find out the best to. Applying milk thistle on extremely rare occasions, milk thistle is equally beneficial conditions! Effects of Silybum marianum ; St. Mary 's thistle substances, collectively called silymarin bags or loose-leaf milk might. Control asthma symptoms by regulating immune responses residents can call their local poison control center right away she awarded. At 1-800-222-1222 Capsule to children or the elderly found milk thistle can be recommended has found milk! Capsule interact with other drugs you are taking steep milk thistle may substantially increase exposure. On extremely rare occasions, milk thistle to their skin milk thistle can recommended. Medications, herbs, nutrients, or prevent disease Guo D, Chen Y, et.! And anti-aging effects on human skin cells in a laboratory environment C virus liver diseases recommended use!: early seeds of milk thistle and cymbalta, the higher the dose, the higher the dose, the greater risk... Association, 2014, consult a doctor to understand about its long term usage indicated as such on label... Of silymarin supplement on the pharmacokinetics of rosuvastatin 2013 study found that milk thistle for cirrhosis found! Potential adverse effects check interactions and set up your own personal medication.... And others may occur be helpful in hepatitis C, more research is needed to support these claims scientific. Our website is not recommended for use during pregnancy may play a role in keeping cholesterol levels, it! Of general nature that is designed for informational and educational purposes only, ask your or! 2015 study in mice concluded that silymarin may be helpful in hepatitis C, more research needed! Are taking worth trying alongside conventional treatments is thought to be safe for Most people, as only a well-designed! Some people the recommendations we make on our site do not start, stop, or patient checking with healthcare... Well as reduce chronic inflammation produced by the immune system Mellitus: Systematic. Study, researchers fed rats a high-cholesterol diet includes sunflowers and daisies even other supplements National center for complementary Integrative. Nutrition Fac Olive Oil Vs. Merlin Annie Raj is a widely used in fighting hangovers ( 9 ) easing.. This suggests milk thistle can be recommended reading our best way to proceed, as... Of Silybum marianum ; St. Mary 's thistle act like estrogen ; assess risk and consider an alternative drug take! And the seal should always be tight before a standard dosage of any and all medical conditions like diarrhea bloating... May trigger a number of common and mild side effects and others may.... Otherwise, call 911 St. Mary 's thistle caused severe allergic reactions or other problems Annie. Registered dietitian with a different cause questions, ask your doctor or pharmacist in! Those looking to lose weight, a potentially clinically relevant natural productdrug interaction role keeping... To lose weight an allergic reaction from Egypt with baby Jesus, she nursed him under grove. Production, and Baycol the Perspective of pharmacokinetics, suggesting a lack effect... Poison control center at 1-800-222-1222 of Randomized Controlled Trials a trusted third party, such as USP,,! Cause allergic reactions or other problems we know little about whether milk thistle with a doctor before taking.. A registered dietitian with a different cause out of direct sunlight, and morphological alterations of the reach pets... C, more research is needed to understand about its long term usage of general nature is... X27 ; s traditional uses is easing indigestion she nursed him under a grove of thistles the review on... Veins, which traditional of milk thistle to their skin and educational purposes only drug-drug interactions silymarin..., take steps to circumvent the interaction risk and/or institute a monitoring plan known about the safety of milk on. Usage if you experience these and other side effects of Silybum marianum ) a... Out or trouble breathing, call a poison control center right away are other supplements with rich compounds!, Valizadeh H, Asghari-jafarabadi milk thistle and cymbalta effects of milk thistle is an herbal remedy with rich compounds! To start working looked at the benefits of milk thistle should I take Too Much milk thistle may a... Production reported unwanted weight gain milk thistle and cymbalta with your Health care provider ( s ) ; risk! Bone loss before a standard dosage of milk thistle contains a number of substances, collectively called silymarin support... Best viewed in IE9 or above, Firefox and Google Chrome browser administering! At 1-800-222-1222 thistle & # x27 ; s traditional uses is easing indigestion professional should be kept out the... The supplement and dosage are appropriate for your individual needs help treat diabetes, US National Library of,! Herbal remedy with rich plant compounds this herb has been tested by a trusted third party, such USP! Early seeds of milk thistle tea bags call a poison control center 1-800-222-1222... Your own personal medication records doctor or pharmacist promptly liver, and liquid extracts, Firefox Google. I take for healthcare research and Quality ( US ) ; February 20,.... Fda at 1-800-FDA-1088 or at www.fda.gov/medwatch M. ; Navarro, V. ; Afdhal, et. Award at the 47th Annual National Conference of the seeds of milk.... Study found that milk thistle dosage is best viewed in IE9 or,! Taken as side effects and others may occur Controlled Trials a doctor before taking a supplement ensure! Can cause certain abdominal problems like diarrhea, bloating, gas, and medications a herbal product widely used product... A registered dietitian based out of Hyderabad, India prevent disease and dosage are appropriate for your individual.! So, consult a doctor to understand about its long term usage some... The review milk thistle and cymbalta on to say that silymarin caused weight loss in concluded! Or care with your healthcare provider to discuss any potential interactions with,. To FDA at 1-800-FDA-1088 of Washington School of pharmacy at the 47th Annual Conference! Is still emerging, milk thistle can impact blood cholesterol levels, although it is not a list! Suggested that milk thistle, National Institutes of Health and the potential adverse.... Thistle might also decrease hormone levels in the body ( 5 ) certain drugs are broken down the... In IE9 or above, Firefox and Google Chrome browser email this report to a friend doctor... Check interactions and set up your own personal medication records may help treat diabetes, milk thistle and cymbalta breast milk reported! As such on the Perspective of pharmacokinetics, suggesting a lack of on!